http://coopfirst.com/faq.htm
Exelixis (NASDAQ: EXEL) also will receivee guaranteed research fundingof $21 milliojn over three years from the French drugmake (NYSE: SNY), but over several years could win $1 billion in regulatory and commercial milestone payments. Sanofi-Aventis will have an exclusive worldwids license for the oralcompoundds XL-147, which is in a Phasse I trial by Exelixis, and XL-765, whicu is in Phase Ib/II. It will have sole responsbility for allsubsequent clinical, commercial and manufacturing work, while Exelixis will help conducr ongoing and potential future clinical trials and manufacturing.
The deal was foreshadowexd at last week’s conference in San Francisco, where Exelixiw CEO George Scangos said a partnershipfor XL-1467 and XL-765 was a goal for the first half of this “That gives us a little more than a month to meet that he said at the time. Exelixixs is scheduled to present data June 1 from Phase I trials of the two compounds at the annual meetinvgin Orlando, Fla. Both compoundes target an enzymecalled phosphoinositide-3 or PI3K. It is one of the most frequentlyh dysregulated pathways inhuman tumors, Scangos said, playinhg a key role in tumofr growth, proliferation, survival and resistance.
Over the long term, Exelixis and Sanofi-Aventias will combine efforts on several preclinicalk programs aroundPI3K inhibitors. Those drugs are likelt to work in combinatiobn with other cancer fighters and on a varietyy oftumor types, Scangos said at the JMP Securitiez conference. “But the development path is complexand expensive,” Scangoss said. “I’m not sure we could pay our half, even if it was 50-5 0 — so they’re great candidates to partner.” Exelixixs may be responsible for certain clinical it said in a pressrelease Thursday. The deal is second this month.
paid $15 million upfront with the potentialof $339 million in milestone and royalty paymente — to develop and commercialize agonists of sphingosine-1-phosphate type 1 receptor, or S1P1, which is implicated in several autoimmunse diseases.
Monday, August 30, 2010
Saturday, August 28, 2010
A Boom in Bonds Hurts Mutual Funds - BusinessWeek
http://campaignfinancesite.org/giving/soft1.html
A Boom in Bonds Hurts Mutual Funds BusinessWeek Burned by two market crashes in a decade, investors have shunned stocks for the longest stretch in more than 23 years, upsetting the ... |
Thursday, August 26, 2010
How to expand your entrepreneurial vision - bizjournals:
http://2wc.info/node/58
But changing is easier said than done. How do you acquirr a fresh perspective? How do you open your mind to newpossibilities ? You start by at least considering opportunities you woul never have entertained in the by trying to approach problems from a differen angle, by venturing outside your comfort zone and by taking some carefully measured If you keep asking yourself the same you’re going to keep getting the same So, let’s tickle your brain and switch up the Let’s view your business throug h fresh eyes. Take a look at your products, salews Let’s look at your sales upside What is ityou aren’t selling? Think of all the recenrt sales you failed to close.
What were the reasonsx your would-be customers gave you? • Are your customeres asking for a product or service thatyou don’t offer? In that case, is it time to expane your portfolio to include something new? Are customers objecting to your prices? Should you re-evaluate your pricinb methodology? Provide less expensivew version of current offerings? Expand payment termes to make purchasing more attractive? Are customers asking for smaller quantitiesd than your current minimums allow? In a soft market, increasing throughput is smart. Can you adjustr your work flow to make smallerorders profitable? Think back over the past year or so.
Is there anything different aboutyour customers? For example, one entrepreneu I know owns a martial arts In the past, he’d requirw that students register for six month s of classes at a time. Back in the good old customers signed up withoutthinking twice. Today, registrations are Yet he’s still sticking to his six-month because “I have to pay my The problem is, customers are increasingly unwilling to commiftto six-month programs. What if their kids lose interest ? What if a parent loses his orher job? His classesx haven’t changed, but his customers have. Because of the tigh economy, they’ve become commitment-shy.
If he wantsw their business, he’ll find a way to accommodate For example, he could offefr month-to-month memberships. Or, he could take a cue from the auto industrt and guarantee tuition refunds if someone losesa job. Yes, he has to pay the But getting the rent money one montyh at a time beats not getting itat all. He’w operating under an outdated assumption. Now, what about you? Are you operatinb by obsolete “rules” that discourags customers from buying? Now, look at yourself Durin g tough times, entrepreneurs have to steel themselves to do thinge theyfind unpleasant. This is true.
However, if you’rre brainstorming ways to strengthenyour business, it helpsa to focus on those aspects you most Chances are, these are your If you like what you’r doing, you’re more likely to stick with it. So ask what is it you like best abou tyour business? What strengths can you buil d on? What areas can you grow? For example, are there related services you’ve thought abourt offering your customers, but never have? Perhaps now is the time to act.
Ray Silversteib is president of PRO: President’ds Resource Organization, a network of entrepreneurial peer advisor groups in Phoenix and He also is the authorof “Thse Best Secrets of Great Small Businesses” and a columnisft for Entrepreneur.com. You can reach him at 800-818-0150 or
But changing is easier said than done. How do you acquirr a fresh perspective? How do you open your mind to newpossibilities ? You start by at least considering opportunities you woul never have entertained in the by trying to approach problems from a differen angle, by venturing outside your comfort zone and by taking some carefully measured If you keep asking yourself the same you’re going to keep getting the same So, let’s tickle your brain and switch up the Let’s view your business throug h fresh eyes. Take a look at your products, salews Let’s look at your sales upside What is ityou aren’t selling? Think of all the recenrt sales you failed to close.
What were the reasonsx your would-be customers gave you? • Are your customeres asking for a product or service thatyou don’t offer? In that case, is it time to expane your portfolio to include something new? Are customers objecting to your prices? Should you re-evaluate your pricinb methodology? Provide less expensivew version of current offerings? Expand payment termes to make purchasing more attractive? Are customers asking for smaller quantitiesd than your current minimums allow? In a soft market, increasing throughput is smart. Can you adjustr your work flow to make smallerorders profitable? Think back over the past year or so.
Is there anything different aboutyour customers? For example, one entrepreneu I know owns a martial arts In the past, he’d requirw that students register for six month s of classes at a time. Back in the good old customers signed up withoutthinking twice. Today, registrations are Yet he’s still sticking to his six-month because “I have to pay my The problem is, customers are increasingly unwilling to commiftto six-month programs. What if their kids lose interest ? What if a parent loses his orher job? His classesx haven’t changed, but his customers have. Because of the tigh economy, they’ve become commitment-shy.
If he wantsw their business, he’ll find a way to accommodate For example, he could offefr month-to-month memberships. Or, he could take a cue from the auto industrt and guarantee tuition refunds if someone losesa job. Yes, he has to pay the But getting the rent money one montyh at a time beats not getting itat all. He’w operating under an outdated assumption. Now, what about you? Are you operatinb by obsolete “rules” that discourags customers from buying? Now, look at yourself Durin g tough times, entrepreneurs have to steel themselves to do thinge theyfind unpleasant. This is true.
However, if you’rre brainstorming ways to strengthenyour business, it helpsa to focus on those aspects you most Chances are, these are your If you like what you’r doing, you’re more likely to stick with it. So ask what is it you like best abou tyour business? What strengths can you buil d on? What areas can you grow? For example, are there related services you’ve thought abourt offering your customers, but never have? Perhaps now is the time to act.
Ray Silversteib is president of PRO: President’ds Resource Organization, a network of entrepreneurial peer advisor groups in Phoenix and He also is the authorof “Thse Best Secrets of Great Small Businesses” and a columnisft for Entrepreneur.com. You can reach him at 800-818-0150 or
Tuesday, August 24, 2010
For area commercial lenders, 2008 was a mixed bag of good and bad - Wichita Business Journal:
http://riverside-ford.com/Air-Intake/Air-Cleaner-Nut-Ford/
Most lenders saw their loan volumes increase from thepreviouas year, but many say demand for credit from Wichitaq businesses softened drastically late in the year as the economyt soured. “I would definitely say we experienced and saw a significan slowdown in the fourth saysKevin Klein, president of Junction City-basedx , which saw a 15 percent jump in its locall loan portfolio for the year. “Ig may have been more that we went into a period of dealing with all the announcements from the general There was probably a shoc kfactor there. They may have gone a little numb.” For Central National Bank, which has locations acrose eastern Kansas, Wichita represented a bright spot.
The $870 million bank’z loan portfolio dropped slightly from ayear ago, taking into account all its markets. For othee banks, the year provided a mixed bag. Twelver out of 20 top lenders saw increaseds in their commercialloan portfolios. , Wichita’s saw a modest softening in itsloan portfolio, down 3 percentr from the end of 2007. ’s loans dropped by 14 percent. But was up 17 percent. also poster a 17 percent gain. Most othere increases were more modest. Bankeres stressed credit remains available here as other banks acrosss the country suffer from lossesa in their portfolios tied to subprimdemortgage loans.
Still, lenders do say they’v tightened their underwriting standards. In some cases, borrowersw have to come up with more money for down And banks have been much more carefu in making loans for commercial real especially if aproject isn’tt owner-occupied. Some banks are trying to reducr their concentrations inthat sector. Lyndon executive vice presidentfor Intrust, called it a “general tightening.” “Loans that may have been made a year ago mighr get a little more scrutiny,” he says. Otherwise, lenderz have had to battle a lack of Business picked up in some say, but the market isn’tt robust.
“I would definitely say getting commerciapl activity out of existing customers is difficult,” says Clark Boyer, president of , which saw a 19 percent jump in its “I think everybody’s just trying to see wher e this all ends up.” Boyer says the bank added two new lenderx in Wichita last year, who brought new relationships to the bank and helped contribute to its 2008 loan But sometimes, other factors force down a bank’ss loan portfolio. saw the biggest drop in commerciakl loans last year at nearly 18 President Larry Carney says the bank saw an inordinatr numberof payoffs.
our customers did really well or came into some says Carney, whose bank makes commercial real estatde loans.
Most lenders saw their loan volumes increase from thepreviouas year, but many say demand for credit from Wichitaq businesses softened drastically late in the year as the economyt soured. “I would definitely say we experienced and saw a significan slowdown in the fourth saysKevin Klein, president of Junction City-basedx , which saw a 15 percent jump in its locall loan portfolio for the year. “Ig may have been more that we went into a period of dealing with all the announcements from the general There was probably a shoc kfactor there. They may have gone a little numb.” For Central National Bank, which has locations acrose eastern Kansas, Wichita represented a bright spot.
The $870 million bank’z loan portfolio dropped slightly from ayear ago, taking into account all its markets. For othee banks, the year provided a mixed bag. Twelver out of 20 top lenders saw increaseds in their commercialloan portfolios. , Wichita’s saw a modest softening in itsloan portfolio, down 3 percentr from the end of 2007. ’s loans dropped by 14 percent. But was up 17 percent. also poster a 17 percent gain. Most othere increases were more modest. Bankeres stressed credit remains available here as other banks acrosss the country suffer from lossesa in their portfolios tied to subprimdemortgage loans.
Still, lenders do say they’v tightened their underwriting standards. In some cases, borrowersw have to come up with more money for down And banks have been much more carefu in making loans for commercial real especially if aproject isn’tt owner-occupied. Some banks are trying to reducr their concentrations inthat sector. Lyndon executive vice presidentfor Intrust, called it a “general tightening.” “Loans that may have been made a year ago mighr get a little more scrutiny,” he says. Otherwise, lenderz have had to battle a lack of Business picked up in some say, but the market isn’tt robust.
“I would definitely say getting commerciapl activity out of existing customers is difficult,” says Clark Boyer, president of , which saw a 19 percent jump in its “I think everybody’s just trying to see wher e this all ends up.” Boyer says the bank added two new lenderx in Wichita last year, who brought new relationships to the bank and helped contribute to its 2008 loan But sometimes, other factors force down a bank’ss loan portfolio. saw the biggest drop in commerciakl loans last year at nearly 18 President Larry Carney says the bank saw an inordinatr numberof payoffs.
our customers did really well or came into some says Carney, whose bank makes commercial real estatde loans.
Sunday, August 22, 2010
Of course a $99 iOS powered Apple iTV will revolutionize TV - I4U
http://hvmaterialsexchange.com/?p=40
IntoMobile (blog) | Of course a $99 iOS powered Apple iTV will revolutionize TV I4U An iOS powered iTV promises a TV experience that is powered by apps. TV shows could have their own apps that provide more than just the TV episodes. ... Digg founder says Apple iTV launch in September will 'change everything' Apple iTV 'will change everything' says Digg founder Kevin Rose Comments on Apple iTV Launch in September |
Saturday, August 21, 2010
Analysis: No major Haiti risk seen from Wyclef election bar - Reuters
http://bestwork.blogetery.com/2010/08/18/domestic-energy-conservation/
Reuters | Analysis: No major Haiti risk seen from Wyclef election bar Reuters PORT-AU-PRINCE (Reuters) - If protests do break out in Haiti to contest Friday's decision to bar hip-hop star Wyclef Jean from running for the presidency of his earthquake-shattered homeland, they may only be short-lived. ... Wyclef Jean can't run for president Wyclef Jean vows to help Haiti after presidential bid rejected Wyclef Jean out of Haiti election |
Thursday, August 19, 2010
In US 20% believe Obama is Muslim - AFP
http://botswanaprop.com/custom-steel-doors-industrial-steel-doors-residential-steel-doors/
Kansas City Star | In US 20% believe Obama is Muslim AFP WASHINGTON â€" A new poll has found one in five Americans mistakenly believes that President Barack Obama is Muslim, the Washington Post reported Thursday. Despite Obama's attendance in church and his repeated and public statements about his Christian ... Obama's religion...Breaking with the president...Remaining in Iraq Nearly 1 in 5 Americans Thinks Obama Is Muslim, Survey Shows Americans uncertain about Obama's faith |
Tuesday, August 17, 2010
Suicide Bomber Kills 51 at Army Recruitment Center in Baghdad - Voice of America
http://dddesignstudio.net/the-functionalities-of-custom-steel-doors/
Telegraph.co.uk | Suicide Bomber Kills 51 at Army Recruitment Center in Baghdad Voice of America Photo: AP Iraqi officials say at least 51 people have been killed and more than 100 others wounded in a suicide bomb blast outside an army recruitment center in Baghdad. An interior ministry official said the bomber targeted army recruits Tuesday in ... Iraq Suicide Bomber Targets Army Recruits, Kills 51 in Center of Baghdad Suicide bomber kills 59 in Iraq 45 killed, 121 wounded in Iraq suicide bombing |
Sunday, August 15, 2010
With Remarks on Mosque, Obama Enters Risky Debate - New York Times
http://andorra-marketing.com/pick-out-right-steel-door-for-getting-100-security/
Jakarta Post | With Remarks on Mosque, Obama Enters Risky Debate New York Times PANAMA CITY, Fla. â€" Faced with withering Republican criticism of his defense of the right of Muslims to build a community center and mosque near ground zero, President Obama quickly recalibrated his remarks on Saturday, ... Mosque divide enters Florida politics Obama again defends right to put mosque near ground zero Obama redefines what he meant when he supported mosque at Ground Zero |
Friday, August 13, 2010
Heard on the Street: Euro-Zone Growth: Made in Germany - Wall Street Journal
Globe and Mail | Heard on the Street: Euro-Zone Growth: Made in Germany W » |
http://setkitchen.com/Cutlery/Gyutou-Knives/
Wednesday, August 11, 2010
Hero or 'Bag Nazi?' JetBlue Flight Attendant Plans to Hit the Beach - ABC News
The Guardian | Hero or 'Bag Nazi?' JetBlue Flight Attendant Plans to Hit the Beach ABC News Steven Slater, the JetBlue flight attendant and self-professed "bag Nazi" who made a dramatic exit on an emergency slide Monday, is now free and told reporters he is looking forward to "a little down time, a little beach time, ... 'I Would Have Snapped, Too,' Says JetBlue Flight Attendant's Mom Plane angry: Air travel at a breaking point Flight attendant released on bail |
http://c-reaction.net/content/36
Monday, August 9, 2010
Actress Farrow Testifies in War Crimes Trial - Voice of America
The Guardian | Actress Farrow Testifies in War Crimes Trial Voice of America Photo: AP American actress Mia Farrow says she heard British supermodel Naomi Campbell tell people she had received a "huge diamond" from former Liberian President Charles Taylor. Farrow told Taylor's war crimes trial in The Hague Monday that she ... Supermodel's Former Agent Carole White Says Campbell 'Flirted' With Dictator ... Profile: Mia Farrow Farrow rejects Campbell's gem claim |
http://www.anvilinformatics.com/company-phoffman.html
Saturday, August 7, 2010
International Assistance Mission slayings: part of Taliban war strategy - Christian Science Monitor
The Guardian | International Assistance Mission slayings: part of Taliban war strategy Christian Science Monitor The Taliban in Afghanistan are claiming responsibility for the attack on an International Assistance Mission medical team, in which 10 people died. The attack is one of the deadliest for American aid workers since the Afghanistan war began. ... Briton, Six Americans on Medical Mission Murdereed in Afghanistan Ambush 10 Aid Workers, Including 6 Americans, Killed in Afghanistan Taliban claims responsibility for killing foreigners |
blogspot.com
Thursday, August 5, 2010
Missouri School Buses Crash, Kill 2 and Injure as Many as 50 - ABC News
CBC.ca | Missouri School Buses Crash, Kill 2 and Injure as Many as 50 ABC News Two school buses loaded with children from a band camp and a tractor trailer collided on a Missouri highway today, killing at least two people and injuring as many as 50 others. The first pictures from the scene show two large yellow ... 2 dead, dozens hurt in school bus crash in Mo. 2 Dead, Dozens Injured as School Buses Crash on Mo. Highway 2 dead, as many as 50 hurt in Missouri school bus accident |
blogspot.com
Tuesday, August 3, 2010
Newspaper Reports Death Toll Rises to 8 in Conn. Workplace Shooting - FOXNews
msnbc.com | Newspaper Reports Death Toll Rises to 8 in Conn. Workplace Shooting FOXNews August 3, 2010: A company executive says a warehouse worker who had been c » |
livejournal.com
Sunday, August 1, 2010
Got $12 Million? Clinton Wedding Could Boost Bid to Sell Historic Mansion - FOXNews
The Hindu | Got $12 Million? Clinton Wedding Could Boost Bid to Sell Historic Mansion FOXNews Astor Courts, located in Rhinebeck, NY, was the venue of Chelsea Clinton's wedding to Marc Mezvinsky. (AP Photo) A historic mansion that was languishing for months on the real estate market could attract new eyes after Chelsea Clinton made it the ... Clinton-Mezvinsky wedding reflects uniting of religions in USA Just Married: Mr. and Mrs. Marc Mezvinsky NY village turns Chelsea theme park as Clinton girl says 'I do' |
victoria0douglas.wordpress.com
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